Design, Synthesis and Characterization of 1,2-Phenylenediamine Functionalized Poly(Maleic Anhydride-alt-Vinyl Acetate) as a Potential New Bioactive Formulation

This study includes the design, synthesis and characterization of 1,2-phenylenediamine (o-PDA) functionalized maleic anhydride (MA)-vinyl acetate (VA) copolymer-based conjugate to develop a new formulation. The molecule is fluorescent dye that allows designing chemotherapeutic polymeric molecules. Poly(maleic anhydride-alt-vinyl acetate) [Poly(MA-alt-VA)] was obtained via charge transfer complex (CTC) radical polymerization presence methyl ethyl ketone (MEK), utilizing benzoyl peroxide (BPO) free-radical initiator at 80 °C, as potential functional carrier. Structural surface poly(MA-alt-VA)/1,2-PDA performed by Attenuated Total Reflectance-Fourier Transform Infrared (ATR-FTIR) Nuclear Magnetic Resonance (1H-NMR). Spectroscopic methods water solubility results confirmed conjugation took place successfully after ring opening reaction amidation mechanism.